Put Kids First in Cancer Research
Join us at the AACR Annual Meeting 2025.
McCormick Place Convention Center
Chicago, IL
Catch Kids First live in Chicago
Attending the annual American Association of Cancer Research® (AACR) Annual Meeting 2025? Explore the robust data and powerful data, tools, and resources available through the Gabriella Miller Kids First Data Resource Center (Kids First DRC).
Chat with our team, learn how you can accelerate discovery, and put kids first in cancer research.
Connect with a Pediatric Cancer Cross-Disease Expert
Hear from Dr. Philip Lupo as he discusses the epidemiologic and genomic overlap between development and childhood cancer.
Session
Session SY33
Developmental Origins of Childhood Cancer
Philip J. Lupo, PhD
Professor of Pediatrics & Hematology-Oncology, Baylor College of Medicine
Epidemiologic and genomic insights into the overlap between development and childhood cancer.
April 29, 2025, 1:25 PM – 1:45 PM
Room E450 B – McCormick Lakeside Center (Level 4)
Curated Collection of Childhood Cancer Discovery
Interact with a curated collection of scientific poster presentations showcasing the latest advancements in pediatric cancer research made possible with Kids First DRC data. Be sure to catch posters from these Kids First scientists.
Session
LBPO.BCS02
Late-Breaking Research: Bioinformatics, Computational Biology, Systems Biology, and Convergent Science 2
Yiran Guo, PhD
Supervisor Bioinformatics Scientist
Children’s Hospital of Philadelphia, Center for Data Driven Discovery in Biomedicine
LB340 / 3 – Analyzing both germline and somatic variants using Variant WorkBench in the Kids First Data Resource Portal: Children’s Brain Tumor Network as an example
April 29, 2025, 2:00 PM – 5:00 PM
Section 52
Talk with Yiran about Gabriella Miller Kids First DRC
Session
PO.BCS01.04
Database Resources
Jack DiGiovanna
Cancer data aggregator: a new cancer data discovery tool
April 27, 2025, 2:00 PM – 5:00 PM
Section 46
Riaz Gillani
Directly engaging participants in rare cancer research is feasible: the osteosarcoma and leiomyosarcoma projects
April 27, 2025, 2:00 PM – 5:00 PM
Section 27
Session
MS.BCS01.01
Artificial Intelligence and Machine Learning for Basic and Translational Research
Robert L. Grossman
Improved diagnosis of non-melanoma skin cancer in resource-limited settings
April 27, 2025, 3:50 PM – 4:05 PM
Room S103 – McCormick Place South (Level 1)
Shawn Levy
A cancer patient survival study facilitated by an integrated enrichment workflow streamlined DNA and RNA sequencing of biopsy samples
April 27, 2025, 2:00 PM – 5:00 PM
Section 42
Session
MS.TB05.01
Advancing the Science of Childhood Cancers: From Bench to Bedside
John M. Maris
The PLK4 inhibitor RP-1664 drives centriole modulation and single agent tumor regressions in preclinical neuroblastoma models
April 27, 2025, 3:20 PM – 3:35 PM
Location to be announced
Session
PO.PS01.06
Cancer Disparities in Behavioral, Psychological, Psychosocial, and Molecular Factors
Philip J. Lupo
Racial and ethnic disparities in incidence of Langerhans cell histiocytosis differ across age groups
April 28, 2025, 9:00 AM – 12:00 PM
Section 40
Session
ED53
Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care
Sharon E. Plon.
Childhood cancer predisposition syndromes: Genetic testing and interpreting results in different settings
April 26, 2025, 10:01 AM – 10:21 AM
Room S403 – McCormick Place South (Level 4)
Session
PO.TB05.01
Developmental Origins and Drivers of Pediatric Cancers
John M. Maris
A human stem cell model of neuroblastoma reveals candidate drivers of tumorigenesis on chromosome 17q
April 28, 2025, 2:00 PM – 5:00 PM
Section 4
Session
PO.MCB08.02
High-Throughput Sequencing / Microarrays / Next-Generation Sequencing
Shawn Levy
A novel integrated target capture and rapid sequencing workflow for myeloid malignancy mutation detection within 12 hours
April 29, 2025, 9:00 AM – 12:00 PM
Section 10
Session
PO.PS01.12
Breaking Barriers in Cancer Care: Addressing Disparities and Improving Outcomes
Jenny Poynter
Rural and urban disparities in distance to childhood cancer survivorship care
April 29, 2025, 2:00 PM – 5:00 PM
Section 41
Session
MS.ET09.01
Degraders and Glues
John M. Maris
Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers
April 29, 2025, 3:55 PM – 4:10 PM
Room S404 – McCormick Place South (Level 4)
Session
PO.CL07.02
Advances in Translational Pediatric Cancer Research
John M. Maris
The B7-H3 targeting antibody-drug conjugate (ADC) vobramitamab duocarmazine (vobra duo) is potently effective against a broad panel of pediatric solid tumor xenograft models: A study from the Pediatric Preclinical In Vivo Testing (PIVOT) Consortium
April 30, 2025, 9:00 AM – 12:00 PM
Section 28
John M. Maris
The CLK/DYRK inhibitor SM09419 shows potent efficacy across a broad panel of pediatric preclinical xenograft models – A report from the Pediatric Preclinical In Vivo Testing Consortium (PIVOT)
April 30, 2025, 9:00 AM – 12:00 PM
Section 28
Andrew Hong
SMARCB1 missense mutants destabilize SWI/SNF complex stability and remodeling activity
April 27, 2025, 2:00 PM – 5:00 PM
Section 41
Session
SY34
Fusion Oncoprotein-driven Malignancies: From Mechanisms to Therapies
Charles G. Mullighan
Targeting the NUP98 fusion oncoprotein interactome
April 27, 2025, 2:25 PM – 2:40 PM
Room E450 B – McCormick Lakeside Center (Level 4)
Session
MS.TB05.01
Advancing the Science of Childhood Cancers: From Bench to Bedside
Charles Mullighan
Diverse mechanisms of therapy resistance in relapsed childhood B-cell acute lymphoblastic leukemia (B-ALL): a report from the Children’s Oncology Group
April 27, 2025, 4:20 PM – 4:35 PM
Location to be announced
Session
MS.MD01.04
Cutting-Edge Advances in Hematology: CAR-T Therapy, B-cell Transformation, Leukemia Mechanisms, and Targeted Drug Development
Charles G. Mullighan
Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML
April 28, 2025, 2:50 PM – 3:05 PM
Room S402 – McCormick Place South (Level 4)
Session
PO.CL13.03
Molecular Genetics and Epigenetics of Tumors
Charles G. Mullighan
Advancing WGS and WTS diagnostic testing for pediatric leukemia: fast-tracking CNV, ploidy, and fusion oncogene detection in 5 days
April 30, 2025, 9:00 AM – 12:00 PM
Section 34
Session
PO.MD01.01
AACR Project GENIE Use Cases
Allison Heath
cBioPortal for cancer genomics
April 27, 2025, 2:00 PM – 5:00 PM
Section 48
Supercharge Your Research Discovery
Kids First DRC is a groundbreaking, NIH-supported program that provides open access to high-quality pediatric cancer data with the tools and resources to optimize it. We empower researchers to accelerate discoveries and develop new treatments for children facing cancer and other rare diseases.