Sequence Data & Sequencing Centers

The Kids First Program generates high-quality whole genome sequence data, and whole exome and transcriptome for tumors/affected tissue along with related clinical data, to discover genetic variants that contribute to pediatric conditions. Making this data as accessible as possible to the research community enables researchers to easily combine/compare datasets for cross-dataset analyses. For Germline or Normal samples WGS is supported at 30X coverage and for Tumor or Affected tissue Whole Genome Sequencing is supported at 30X coverage in addition to 100X for whole exome sequencing and 100X for RNAseq.

DNA Sequencing Stock

Four centers were selected to perform the sequencing for the Kids First Program:

Broad Institute of MIT & Harvard (link is external)
  • Stacey Gabriel, Ph.D., Senior Director, Genomics Platform
  • Michael Talkowski, Ph.D.
  • Daniel MacArthur, Ph.D.