Sequence Data & Sequencing Centers
The Kids First Program generates high-quality whole genome sequence data and, in some cases, whole exome and transcriptome data for tumors or affected tissue to discover genetic variants that contribute to pediatric conditions. Making these data as accessible as possible to the research community enables researchers to easily compare datasets for cross-dataset analyses. For Germline or Normal DNA is typically Whole Genome Sequenced at an average of 30X coverage. A variety of approaches may be taken for sequencing of tumors or affected tissue, such as 30X whole genome sequencing, combined with 100X whole exome and 100X RNA sequencing.
Four centers were selected to perform the sequencing for the Kids First Program:
HudsonAlpha Institute for Biotechnology
(link is external)
- Shawn Levy, Ph.D, Director of the Genomic Services Lab
- Jinghui Zhang, Ph.D.
- John Easton, Ph.D.
Broad Institute of MIT & Harvard
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- Stacey Gabriel, Ph.D., Senior Director, Genomics Platform
- Michael Talkowski, Ph.D.
- Daniel MacArthur, Ph.D.
Baylor College of Medicine Human Genome Sequencing Center
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- Richard Gibbs, Ph.D., Director Human Genome Sequencing Center Baylor College of Medicine
McDonnell Genome Institute at Washington University
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- Susan Dutcher, Ph.D., Interim Director, The Institute for Genomic Medicine