The Annual Meeting of the American Association for Cancer Research (AACR) covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in cancer research and medicine from institutions all over the world. AACR will hold its 2019 Annual Meeting from March 29 to April 3 at the Georgia World Congress Center in Atlanta, GA.
At this world-class meeting of cancer experts, the National Institutes of Health (NIH) Common Fund-supported Gabriella Miller Kids First Data Research Center (Kids First DRC) will present an exhibition, where attendees can learn more about the recently-launched Gabriella Miller Kids First Data Resource Portal and related datasets. In addition to structural birth defect data, the portal currently has two cancer-specific datasets available for access: the Pediatric Brain Tumor Atlas (PBTA) and a dataset focused on the genetic risk of Ewing sarcoma. The Kids First DRC Exhibition Booth will be located on the Exhibitor Floor in booth number 4162.
Released in September of 2018, the PBTA is comprised of data from over 30 different types of pediatric brain tumors representing over 1,000 subjects. Data types include matched tumor/normal, whole genome data (WGS), RNAseq, proteomics, longitudinal clinical data, imaging data including MRIs and radiology reports, histology slide images, and pathology reports. Also released in September 2018, the Ewing sarcoma dataset includes whole genome sequence data and trio-based variants from over 1,000 subjects.
The data within the Gabriella Miller Kids First Data Resource Portal are accessible for approved research projects. Additional information about the available datasets can be found at https://kidsfirstdrc.org/support/studies-and-access/
Throughout the week-long meeting, Kids First DRC experts in platform development and genomic and phenotypic harmonization, as well as representatives from the NIH will be on-hand at the exhibition booth to hold live Portal demonstrations and walkthroughs, answer questions, and provide additional information. Meeting attendees will also have the opportunity to learn how they can apply for cloud storage and compute credits to support analysis of Kids First data on Cavatica.
Personnel within the Kids First DRC Administrative & Outreach Core, Data Resource Portal Core, and Data Coordination Core, as well as a number of Kids First X01 Investigators specializing in pediatric cancers will also be presenting posters and presentations throughout the event:
Kids First DRC Posters and Presentations
April 1, 2019
Poster: Gabriella Miller Kids First Data Resource Center: Harmonizing Clinical and Genomic Data to Support Childhood Cancer and Structural Birth Defect Research
1:00pm-5:00pm; Section 31, 2464 / 4
https://www.abstractsonline.com/pp8/#!/6812/presentation/6063
Poster: Genomic Harmonization of the Data Resource Center for the Gabriella Miller Kids First Pediatric Research Program
1:00pm-5:00pm; Section 31, 2465 /5
https://www.abstractsonline.com/pp8/#!/6812/presentation/6064
April 2, 2019
Poster: Working Together to Put Kids First: Outreach Strategies Driving Collaborative Research, Data Sharing, and Cross-Disease Analysis to Accelerate Discoveries in Pediatric Cancer and Structural Birth Defects
8:00am-12:00pm; Section 29, 3356 / 22
https://www.abstractsonline.com/pp8/#!/6812/presentation/7717
Kids First DRC Consortia Partner Posters and Presentations
April 2, 2019
Poster: The Pediatric Brain Tumor Atlas – Transforming the Landscape of Research
1:00pm-5:00pm; Section 2, 3667 / 25
https://www.abstractsonline.com/pp8/#!/6812/presentation/3703
Kids First X01 Investigators Presenting at AACR 2019:
April 1, 2019
Poster: DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio and Survival Among Pediatric Medulloblastoma Patents
Philip J. Lupo, PhD, MPH; Baylor College of Medicine
8:00am-12:00pm; Section 26, 1575 /14
https://www.abstractsonline.com/pp8/#!/6812/presentation/2006
Poster: Loss of Function of GAS7 Promotes Neuroblastoma Metastasis in the Context of MYCN Overexpression
John M. Maris, MD; Children’s Hospital of Philadelphia
1:00pm-5:00pm; Section 41, LB-127 / 3
https://www.abstractsonline.com/pp8/#!/6812/presentation/9318
Session AOS01 – Genetic Predisposition in Hematologic Malignancies
Chairperson: Charles G. Mullighan, MBBS(Hons), MSc, MD; St. Jude Children’s Research Hospital
1:00pm; Room B401 – Georgia World Conference Center
https://www.abstractsonline.com/pp8/#!/6812/presentation/298
Presentation: Germline Determinants of Susceptibility and Drug Response in Acute Lymphoblastic Leukemia
Charles G. Mullighan, MBBS(Hons), MSc, MD; St. Jude Children’s Research Hospital
2:00pm-2:25pm; Room B401 – Georgia World Conference Center
[https://www.abstractsonline.com/pp8/#!/6812/presentation/8206] (https://www.abstractsonline.com/pp8/#!/6812/presentation/8206)Poster: Exploring the Complex Etiology of Oncogenic Fusions in Childhood Cancer
Joshua D. Schiffman, MD; Huntsman Cancer Institute
1:00pm-5:00pm; Section 33, 2506 / 2
https://www.abstractsonline.com/pp8/#!/6812/presentation/3480
April 2, 2019
Poster: The Hippo Pathway Protein YAP Mediates Resistance to MEK1/2 Inhibition in Neuroblastoma
John M. Maris, MD; Children’s Hospital of Philadelphia
8:00am-12:00pm; Section 6, 2886 / 22
https://www.abstractsonline.com/pp8/#!/6812/presentation/3696
Poster: Serial Profiling of ctDNA Identifies Clinically Actionable Genomic Evolution in High-Risk Neuroblastoma
John M. Maris, MD; Children’s Hospital of Philadelphia
8:00am-12:00pm; Section 19, 3105 / 3
https://www.abstractsonline.com/pp8/#!/6812/presentation/5958
Poster: A Functional POT1 Variant and Risk of Thyroid Subsequent Malignant Neoplasm: A Report from the Childhood Cancer Survivor Study
Philip J. Lupo, PhD, MPH; Baylor College of Medicine
8:00am-12:00pm; Section 19, 3122 / 20
https://www.abstractsonline.com/pp8/#!/6812/presentation/5975
Poster: Survival Disparities for Second Primary Malignancies Diagnosed Among Childhood Cancer Survivors: A Population-Based Assessment
Philip J. Lupo, PhD, MPH; Baylor College of Medicine
8:00am-12:00pm; Section 27, 3287 / 7
https://www.abstractsonline.com/pp8/#!/6812/presentation/1791
Poster: Genetic Mechanisms of Primary Chemotherapy Resistance in Pediatric Acute Myeloid Leukemia
Soheil Meshinchi MD, PhD; Rhonda Ries; Fred Hutchinson Cancer Research Center
8:00am-12:00pm; Section 6, 2870 / 6
https://www.abstractsonline.com/pp8/#!/6812/presentation/3659
Poster: Integrative Mass Spectrometry and RNA-sequencing Identifies DLK1 as a Candidate Immunotherapeutic Target in Neuroblastoma
John M. Maris, MD; Children’s Hospital of Philadelphia
1:00pm-5:00pm; Section 2, 3650 / 8
https://www.abstractsonline.com/pp8/#!/6812/presentation/3674
Poster: Acetate Supplementation Eliminates Hypoxia Mediated Resistance to Differentiation Therapy in Neuroblastoma Cells
John M. Maris, MD; Children’s Hospital of Philadelphia
1:00pm-5:00pm; Section 10, 3798 / 3
https://www.abstractsonline.com/pp8/#!/6812/presentation/1562
Poster: Poly(ADP-ribose) Polymerase 1 (PARP-1) Targeting Radionuclides are Highly Cytotoxic Across a Panel of 20 Neuroblastoma Cell Lines
John M. Maris, MD; Children’s Hospital of Philadelphia
1:00pm-5:00pm; Section 15, 3921 / 2
https://www.abstractsonline.com/pp8/#!/6812/presentation/870
Poster: The Genomic Landscape and Clonal Evolution of Tumours Arising in TP53 Mutation Carriers
Joshua D. Schiffman, MD; Huntsman Cancer Institute
1:00pm-5:00pm; Section 2, 3666 / 24
https://www.abstractsonline.com/pp8/#!/6812/presentation/3702
April 3, 2019
Poster: Re-Evaluating Sample Sizes in Preclinical Testing of Patient-Derived Xenografts
John M. Maris, MD; Children’s Hospital of Philadelphia
8:00am-12:00pm; Section 42, LB-321 / 12
https://www.abstractsonline.com/pp8/#!/6812/presentation/9345
Poster: Medical Radiation Exposure and Risk of Retinoblastoma: A Report from the Children’s Oncology Group
Philip J. Lupo, PhD, MPH; Baylor College of Medicine
8:00am-12:00pm; Section 26, 5039 / 3
https://www.abstractsonline.com/pp8/#!/6812/presentation/1838
Poster: Are Co-Occurring Structural Birth Defects Associated with Risk of Acute Lymphoblastic Leukemia Among Children with Down Syndrome
Philip J. Lupo, PhD, MPH; Sharon E. Plon, MD, PhD; Karen R. Rabin, MD, PhD; Baylor College of Medicine
8:00am-12:00pm; Section 26, 5054 / 18
https://www.abstractsonline.com/pp8/#!/6812/presentation/1997
