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annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions.

Background: Gene fusion events are significant sources of somatic variation across
adult and pediatric cancers and are some of the most clinically-effective
therapeutic targets, yet low consensus of RNA-Seq fusion prediction
algorithms makes therapeutic prioritization difficult. In addition, events
such as polymerase read-throughs, mis-mapping due to gene homology, and
fusions occurring in healthy normal tissue require informed filtering,
making it difficult for researchers and clinicians to rapidly discern gene
fusions that might be true underlying oncogenic drivers of a tumor and in
some cases, appropriate targets for therapy.

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