Background: The germline genetic events underpinning medulloblastoma (MB) initiation,
and therefore the ability to determine who is at risk, are still unknown
for the majority of cases. Microsatellites are short repeated sequences
that make up ~3% of the genome. Repeat lengths vary among individuals and
are often nonrandomly associated with disease, including several cancers
such as breast, glioma, lung, and ovarian. Due to their effects on gene
function, they have been called the “tuning knobs of the genome.”
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