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Los casos de neuroblastoma y glioblastoma con oncogenes amplificados han reducido el número de recombinaciones de receptores inmunes adaptativos residentes en tumores

Purpose: In certain cancers, oncogene amplification is correlated with an immunologically cold or noninflamed, tumor immune microenvironment (TIME) and a worse prognosis, Por ejemplo, in the case of MYCN-amplified neuroblastoma (NBL). Sin embargo, for other cancer types, the relationship between oncogene amplification and immune response is more complicated or unresolved. One such cancer is glioblastoma multiforme (GBM), in which the epidermal growth factor receptor (EGFR) oncogene is commonly amplified. Unlike MYCN-amplified NBL, EGFR-amplified GBM has not been shown to correlate with a distinct survival probability.

Methods: Given this contrasting state for NBL and GBM, we sought to apply a genomics approach to evaluating the immune response for cases with gene amplification.

Resultados: Our results confirmed and added further specificity to the cold TIME of MYCN-amplified NBL. Además, we demonstrated a novel state of immunologically cold EGFR-amplified GBM tumors.

Conclusion: This approach to using copy number variation and immune receptor recombination read recovery levels to assess gene amplification and TIME, respectivamente, may be particularly efficient for the rapid evaluation of many other cancer types.

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