儿童脑肿瘤中的肿瘤内 T 细胞表现出克隆扩张和效应特性.

Brain tumors in children are a devastating disease in a high proportion of
患者. Owing to inconsistent results in clinical trials in unstratified
患者, the role of immunotherapy remains unclear. We performed an
in-depth survey of the single-cell transcriptomes and clonal relationship
of intra-tumoral T cells from children with brain tumors. Our results
demonstrate that a large fraction of T cells in the tumor tissue are
clonally expanded with the potential to recognize tumor antigens. Such
clonally expanded T cells display enrichment of transcripts linked to
effector function, tissue residency, immune checkpoints and signatures of
neoantigen-specific T cells and immunotherapy response. We identify
neoantigens in pediatric brain tumors and show that neoantigen-specific T
cell gene signatures are linked to better survival outcomes. 尤其, among
我们队列中的患者, 我们观察到很大的异质性
克隆膨胀和T细胞反应的幅度. 我们的发现
表明肿瘤内T细胞反应的表征可以实现
选择患者免疫疗法, 一种需要的方法
临床试验中的前瞻性验证.